Pediatric Head Injury

Minor trauma to the head is common in childhood and does not require any medical or surgical treatment. Nevertheless, head injury in infancy and childhood is the single most common cause of death and permanent disability. Measurable deficits occur even after mild to moderate head injury but are markedly greater after severe injury. They include impaired cognition, motor impairments, disruption of attention and information processing, and psychiatric disturbances. Despite the frequency of the sequelae of head injury in childhood, there is relatively little information about the structural basis of the clinical deficits. Classical literature suggests that the immature brain and its coverings, at a time when it is rapidly acquiring new information, respond differently from the adult brain when subjected to an equivalent amount of mechanical force, whether mediated by contact or inertial loading. Identification of different patterns of injury in different age groups has resonance in clinical practice and now provides a reference point for future clinical and neuropathological studies. This work not only provides the basis for the future management of patients, but also serves to remind us of the continuing value of the autopsy and the proper examination of retained organs using modernstandardized techniques

What is unpaid female labour worth? Evidence from the Time Use Studies of Iran in 2008 and 2009

This paper uses the Time Use Survey of Iran of 2008 and 2009 to estimate the monetary value of unpaid domestic work of urban housewives. The surveys recorded domestic work activities such as cooking and cleaning and general care of household members as well as care of children and their education. Using the market-based approach to estimate the monetary value of unpaid domestic work we collected data on the cost of buying in services for domestic work and for education of children from ‘nursing agencies’ and private education colleges in main cities of Iran in the summer of 2011 that were adjusted to obtain the 2008 and 2009 prices. The market value of domestic work of urban housewives was estimated to be US$25 billion in 2008 and US$29 billion in 2009. These were about 8.6 per cent of non-oil GDP in the same years. Our estimates complement other findings from around the world that confirm substantial contribution of housewives to the economy. These contributions have gone unrecorded and not compensated in most countries. At a minimum, housewives can be insured against basic contingencies of life such has health problems, poverty and disabilities and supported in old age. Our work and other studies do provide the economic and social arguments for costing and putting into practice the long overdue support for housewives; they have earned it

Study of some biological parameters of Tenualosa ilisha and gonad histological characteristics on spawning and post spawning

This research was conducted for studying of biological parameters of Tenualosa ilisha on spawning and post spawning time. For this reason, 60 fish were captured through three months, on September- fresh water (Karoon river in Khorramshahr) (1st station), September marine water (Hendijan coasts) (2nd station), October-marine water (3rd station) and November-marine water (4th station). Biological parameters, GSI and gonad histological study was performed. The results showed the highest total length, total weight and gonad weight were seen in fish were captured from 1st station which has a significant different with other fishes (p<0.05). Microscopic examination showed that 7 fishes were male and 53 were female. Samples of the 1st station were on stage 5 of gonad development and the main oocytes were post ovulated. Samples from other three stations were mainly on preliminary gonadal stages. In these ovaries, primary stages of yolk formation and nucleoli margination and development of yolk vesicles are obvious. Based on these results, Tenualosa ilisha is ready for spawning on September and this period is preferable for artificial propagation of this species

Low dose ribavirin for treatment of HCV infected thalassemia major patients; new indications for combination therapy

Background: Treatment guidelines contraindicate ribavirin for treatment of hepatitis C virus (HCV) infection in thalassemia major patients. Nevertheless, the current evidence suggests that ribavirin might be tolerated by these patients. Objectives: Despite this evidence, low dose ribavirin combination therapy has not been compared with peg interferon monotherapy in these patients so far. Patients and Methods: Two hundred eighty thalassemia patients with detectable HCVRNA PCR (� 50 IU/mL) and liver histology consistent with chronic HCV infection were self-assigned to receive peg interferon alfa-2a (n = 81) monotherapy or its combination therapy with ribavirin, 600-800 mg QD, according to hemoglobin levels (n = 199). Treatment experienced patients were eligible for this study. Results: Sustained virological response (SVR) was significantly higher in patients who received ribavirin (51 vs. 38 P = 0.02). In multivariate regression, OR of ribavirin for prediction of SVR was 2.2 (95 CI 1.24-3.91). The SVR was significantly higher in the ribavirin group in subgroups of patients with more than 24 years of age, elevated ALT, ferritin < 2006 ng/mL, previous treatment failure, genotype 1, positive history of splenectomy, fibrosis score of 0-4 HAI and viral load < 600,000 IU/mL. Treatment discontinuations due to the safety concerns were comparable between the treatment groups (6.5 and 8 ). Furthermore, transfusion intervals were almost halved in patients who received low dose ribavirin. Conclusions: According to the present study, adult thalassemia patients with HCV infection can be treated successfully with low dose ribavirin. Hence, we strongly advise combination therapy in thalassemia patients with aforementioned clinical characteristics. Moreover, ribavirin does not seem to be beneficial in thalassemia patients below 18 years of age. © 2012 Kowsar Corp. All rights reserved

The relationship between information literacy, internet addiction and general health of an Iranian medical students

Introduction: Given the prevalence of Internet use worldwide and its existing risks to societies especially the youngsters, information literacy can affect the use of Internet. Hence, the objective of present study is to assess the relationship between information literacy and Internet addiction and then to investigate the relationship between Internet addiction and general health of students in Iran University of Medical Sciences. Materials and Methods: It is an analytical cross-sectional study which was conducted during 2016 on students in Iran University of Medical Sciences (Tehran, Iran). The sample size for the surveyed community of 6,500 university students was 362 from the Cochran sample size formula. Then, using a simple random sampling method, from each of the colleges, the sample size was selected according to the student population. Three questionnaires of information literacy, Yang's Internet addiction, and general health scale (GHQ-28) were distributed among students. Finally, 365 questionnaires were collected and analyzed. Results: 29.9 of students were about to be addicted to the Internet, 1.3 had symptoms of Internet addiction and 68.8 had no addiction. In terms of information literacy, most of the students were in moderate level (60.5 moderate, 3.3 low, and 36.2 high information literacy level). There was a significant inverse relationship between increasing of information literacy and the Internet addiction (r = -0.45 and p<0.001). The score of general health demonstrated an inverse and significant relationship in different levels of Internet addiction (P <0.001). Conclusion: According to the findings of this study, it was perceived that the higher the information literacy, the lower the level of Internet addiction; besides, reduction of internet addiction increased the general health of students. Therefore, considering the importance of students as the leading group in societies, and favorable consequences of increased information literacy, universities' authorities have to develop and run specific programs within the educational and research schedule in order to increase the students' information literacy. Accordingly, undesirable outcomes of Internet use would be diminished and general health of society would be improved. © 2018, Semnan University of Medical Sciences. All rights reserved

The relationship between information literacy, internet addiction and general health of an Iranian medical students

Introduction: Given the prevalence of Internet use worldwide and its existing risks to societies especially the youngsters, information literacy can affect the use of Internet. Hence, the objective of present study is to assess the relationship between information literacy and Internet addiction and then to investigate the relationship between Internet addiction and general health of students in Iran University of Medical Sciences. Materials and Methods: It is an analytical cross-sectional study which was conducted during 2016 on students in Iran University of Medical Sciences (Tehran, Iran). The sample size for the surveyed community of 6,500 university students was 362 from the Cochran sample size formula. Then, using a simple random sampling method, from each of the colleges, the sample size was selected according to the student population. Three questionnaires of information literacy, Yang's Internet addiction, and general health scale (GHQ-28) were distributed among students. Finally, 365 questionnaires were collected and analyzed. Results: 29.9 of students were about to be addicted to the Internet, 1.3 had symptoms of Internet addiction and 68.8 had no addiction. In terms of information literacy, most of the students were in moderate level (60.5 moderate, 3.3 low, and 36.2 high information literacy level). There was a significant inverse relationship between increasing of information literacy and the Internet addiction (r = -0.45 and p<0.001). The score of general health demonstrated an inverse and significant relationship in different levels of Internet addiction (P <0.001). Conclusion: According to the findings of this study, it was perceived that the higher the information literacy, the lower the level of Internet addiction; besides, reduction of internet addiction increased the general health of students. Therefore, considering the importance of students as the leading group in societies, and favorable consequences of increased information literacy, universities' authorities have to develop and run specific programs within the educational and research schedule in order to increase the students' information literacy. Accordingly, undesirable outcomes of Internet use would be diminished and general health of society would be improved. © 2018, Semnan University of Medical Sciences. All rights reserved

Diagnosis of latent tuberculosis infection among pediatric household contacts of Iranian tuberculosis cases using tuberculin skin test, IFN- γ release assay and IFN-γ-induced protein-10

Background: Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of this high-risk group, mainly because of resource limitations. We aimed to evaluate the prevalence of LTBI among pediatric household contacts of TB cases in two high-burden provinces in Iran. Methods: We conducted a cohort study in children who had been in household contact with a TB index. All subjects were assessed for active TB disease. For LTBI diagnosis, tuberculin skin test (TST) and QuantiFERON®-TB Gold Plus (QFT-Plus) were performed at the time of the index TB case diagnosis, as well as, 3, 12, and 18 months, if the first results were negative. In addition, interferon-γ-induced protein-10(IP-10) concentrations were measured for all participants. Results: A total of 230 children were enrolled, who had contact with an index TB case. Three contacts were diagnosed with active TB. According to the TST/QFT-Plus results, 104 (45.2) children were identified with LTBI during our study. Significantly increased IP-10 levels were found in LTBI patients compared to healthy contacts. Accordingly, more than 50 of LTBI contacts and about 10 of healthy contacts were considered as IP-10-positive. Conclusion: This study alarmingly illustrates a high prevalence of LTBI among Iranian children exposed to TB cases. We, therefore, emphasize that the children living in close contact with an infectious TB case should be screened effectively and receive prophylactic therapy. © 2021, The Author(s)

MIGHTEE : total intensity radio continuum imaging and the COSMOS/XMM-LSS Early Science fields

Please read abstract in the article.The UK Science and Technology Facilities Council; the South African Radio Astronomy Observatory; the Leverhulme Trust through an Early Career Research Fellowship; the South African Research Chairs Initiative of the Department of Science and Technology; the National Research Foundation; the Science and Technology Foundation (FCT, Portugal); the UK STFC ; the South African Research Chairs Initiative of the Department of Science and Innovation; the Bundesministerium für Bildung und Forschung (BMBF); the Italian Ministry of Foreign Affairs and International Cooperation; the South African Department of Science and Technology’s National Research Foundation (DST-NRF).https://academic.oup.com/mnrashj2022Physic

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden